The present manuscript describes simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method for the simultaneous determination of Ceftazidime and Clavulanic acid in bulk and in pharmaceutical dosage form. Absorbance ratio method uses the ratio of absorbance at two selected wavelengths, one which is an isoabsorptive point and other being the λ-max of one of the two components. Ceftazidime and Clavulanic acid show an isoabsorptive point at 269 nm in dist. water. The second wavelength used is 256 nm, which is the λ-max of Ceftazidime in dist. water. The linearity was obtained in the concentration range of 4-16 μg/ml for Ceftazidime and 50-250 μg/ml Clavulanic acid. The concentrations of the drugs were determined by using ratio of absorbance at isoabsorptive point and at the λ-max of Ceftazidime. The method was successfully applied to pharmaceutical dosage form because of no interference. The results of analysis have been validated by recovery studies.
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